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Gene Information
Gene symbol: VEGFC
Gene name: vascular endothelial growth factor C
HGNC ID: 12682
Synonyms: VRP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FLT4 | 1 hits |
| 2 | KDR | 1 hits |
| 3 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16943230 | The ability of VEGF-C to prevent apoptosis induced by TNFalpha or hyperglycaemia in endothelial cells was assessed by flow cytometry. |
| 2 | 16943230 | TNFalpha up regulated both VEGF-C and vascular endothelial growth factor receptor-2 (VEGFR)-2 expression in endothelial cells in a dose-dependent manner, but had no effect on VEGFR-3. |
| 3 | 16943230 | Flow cytometry results showed that VEGF-C prevented endothelial cell apoptosis induced by TNFalpha and hyperglycaemia and that the antiapoptotic effect was mainly via VEGFR-2. |
| 4 | 16943230 | In pericytes, the expression of VEGF-C mRNA remained stable on exogenous TNFalpha treatment. |
| 5 | 16943230 | In retinal endothelial cells, TNFalpha stimulates the expression of VEGF-C, which in turn protects endothelial cells from apoptosis induced by TNFalpha or hyperglycaemia via VEGFR-2 and thus helps sustain retinal neovascularisation. |