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Gene Information
Gene symbol: WNT2
Gene name: wingless-type MMTV integration site family member 2
HGNC ID: 12780
Synonyms: IRP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOS | 1 hits |
| 2 | GSK3B | 1 hits |
| 3 | INS | 1 hits |
| 4 | JUN | 1 hits |
| 5 | SFRP1 | 1 hits |
| 6 | WNT5A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1227847 | Concentrations of immunoreactive insulin activity (IRI) and proinsulin activity (IRP), blood glucose, free fatty acids (FFA), glycerol, cholesterol, triglycerides were analyzed in 140 subjects suspect of protodiabetes and 50 healthy persons before, during and after a glucose infusion test (GIT). |
| 2 | 15754042 | Canonical WNTs (WNT2, WNT2B, etc) activate the beta-catenin-TCF pathway to induce carcinogenesis, while non-canonical WNTs (WNT5A, WNT11, etc) activate the planar cell polarity (PCP) pathway to induce cell motility and metastasis. |
| 3 | 15507471 | Upstream activation of Wnt signaling by the Wnt-2 and Wnt-3a ligands, stable overexpression of Wnt-2, as well as GSK-3beta inhibition by lithium, SB216763, and GSK-3beta dominant negative forms (K85R and R96E) conferred the invasive phenotype through several proinvasive pathways. |
| 4 | 15507471 | Induction of the matrix metalloprotease MMP-7 (matrilysin) gene and protein by Wnt-2 was abolished by inactivation of the AP-1 binding site in the promoter. |
| 5 | 15507471 | Accordingly, invasion induced by Wnt-2 was prevented by soluble FRP-3 and FRP-1, sequestration of Gbetagamma subunits, depletion of the GSK-3beta protein by RNA interference, the c-Jun dominant negative mutant TAM67 and was not reversed by wt-Axin. |
| 6 | 15507471 | Thus, the proinvasive activity of Wnt-2 is mediated by a noncanonical Wnt pathway using GSK-3beta and the AP-1 oncogene. |