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Gene Information
Gene symbol: WT1
Gene name: Wilms tumor 1
HGNC ID: 12796
Synonyms: WAGR, WIT-2, AWT1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DES | 1 hits |
| 2 | IGF1R | 1 hits |
| 3 | IGF2 | 1 hits |
| 4 | NPHS1 | 1 hits |
| 5 | SYNPO | 1 hits |
| 6 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8390684 | IGF-IR gene (designated IGF1R) expression in the tumors was inversely correlated with the expression of the Wilms tumor suppressor gene WT1, whose inactivation appears to be a key step in the etiology of Wilms tumor. |
| 2 | 8390684 | These results suggest that underexpression, deletion, or mutation of WT1 may result in increased expression of the IGF-IR, whose activation by IGF-II may be an important aspect of the biology of Wilms tumor. |
| 3 | 17596726 | Urinary nephrin and synaptopodin expressions are correlated with baseline clinical parameters such as proteinuria or renal function, while WT-1 expression is related to the degree of histological damage. |
| 4 | 21289599 | Further, both agonists restored WT-1 staining along with podocin and nephrin mRNA expression, suggesting podocyte protection. |
| 5 | 21220752 | Immunostaining for Wilms' tumor-1 (WT1) and synaptopodin, markers of podocytes, was attenuated, whereas immunostaining for desmin, a marker of podocyte damage, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, was up-regulated in the glomeruli of diabetic rats. |
| 6 | 21378152 | We aimed to address whether TGF-beta affects WT1 expression in podocytes. |
| 7 | 21378152 | A human podocyte cell line treated with TGF-beta1 and kidneys in Alb/TGF-beta1-transgenic mice were analyzed for WT1 expression. |
| 8 | 21378152 | In cultured podocytes, TGF-beta1 reduced WT1 protein expression determined by western blotting beginning at 8 h and decreased WT1 messenger RNA (mRNA) expression measured by quantitative reverse transcription-polymerase chain reaction beginning at 3 h. |
| 9 | 21378152 | TGF-beta1 did not alter luciferase activity of the reporter construct for a human WT1 promoter but reduced that for a human WT1 5' enhancer construct, suggesting that TGF-beta1 may regulate WT1 expression by altering the 5' enhancer activity. |
| 10 | 21378152 | TGF-beta1 reduces WT1 expression in cultured human podocytes and podocytes in mice before overt glomerulosclerosis begins. |