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Gene Information
Gene symbol: XBP1
Gene name: X-box binding protein 1
HGNC ID: 12801
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF3 | 1 hits |
| 2 | DDIT3 | 1 hits |
| 3 | INS | 1 hits |
| 4 | KLRG1 | 1 hits |
| 5 | PDX1 | 1 hits |
| 6 | PIAS2 | 1 hits |
| 7 | PIK3CA | 1 hits |
| 8 | PIK3R1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20408817 | In the present study we show that XBP1s, the active spliced form of XBP1 protein, is SUMOylated, mainly by PIAS2 [protein inhibitor of activated STAT (signal transducer and activator of transcription) 2] at two lysine residues located in the C-terminal transactivation domain. |
| 2 | 21266249 | Regulatory subunits of PI3K, p85alpha and p85 beta, interact with XBP1 and increase its nuclear translocation. |
| 3 | 20349222 | Surprisingly, XBP1s overexpression impaired glucose-stimulated insulin secretion and increased beta cell apoptosis, whereas it protected fibroblasts against cell death induced by ER-stress. mRNA expression of Pdx1 and Mafa was inhibited in cells overproducing XBP1s, leading to decreased insulin expression. |
| 4 | 20349222 | XBP1s knockdown partially restored cytokine/ER-stress-driven insulin and Pdx1 inhibition but had no effect on cytokine-induced ER-stress and apoptosis. |
| 5 | 20349222 | Prolonged XBP1s production hampers beta cell function via inhibition of insulin, Pdx1 and Mafa expression, eventually leading to beta cell apoptosis. |
| 6 | 21691070 | However, we detected endoplasmic reticulum (ER) stress markers, i. e. a significant upregulation of BiP and CHOP expression as well as XBP1 mRNA splicing. |
| 7 | 21784843 | We have used an insulin-secreting cell line with inducible expression of dominant negative (DN) HNF1?, a transcription factor vital for correct ?-cell development and function, to show that HNF1? is required for Xbp1 transcription and maintenance of the normal ER stress response. |
| 8 | 22033410 | The glucose sensitivity of Atf3(-/-) and WT islets for the stimulation of insulin secretion and Xbp1 mRNA splicing during 18h culture was similar, demonstrating that glucose metabolism was unaffected by Atf3 deletion. |