Ignet

Gene Pair: MAPK1, NOS2A

Related Sentences

#	PMID	Sentence
1	21450974	The objectives of this study were to examine the roles of mitogen-activated protein kinases (MAPKs) and transcription factors (nuclear factor-?B [NF-?B] and activating protein 1 [AP-1]) in peptidoglycan (PGN)-induced iNOS expression and NO production in macrophages.
2	21450974	In contrast, inhibition of the ERK pathway using PD98059 dose dependently enhanced PGN-induced iNOS expression and NO production.
3	21450974	These results indicate that the JNK MAPK positively regulate PGN-induced iNOS and NO expression by activating NF-?B and AP-1 transcription factors, whereas the ERK pathway plays a negative regulatory role via affecting NF-?B activity.