Ignet

Gene Pair: ADH1A, AKR1B1

Related Sentences

#	PMID	Sentence
1	3128293	Placenta aldose reductase exhibited no cross-reactivity with aldehyde reductase from human liver in an ELISA assay.
2	8343612	Aldehyde reductase is primarily localized in the cortex, while the medulla contains aldose reductase.
3	8343612	Purified aldose reductase utilizes aldose sugars such as D-xylose, D-glucose, and D-galactose as substrates while aldehyde reductase preferentially reduces D-glucuronate and oxidizes L-gulonate to D-glucuronate.
4	15465344	The lead candidate, example 40, 5-fluoro-2-(4-bromo-2-fluoro-benzylthiocarbamoyl)-phenoxyacetic acid, inhibits aldose reductase with an IC(50) of 30 nM, while being 1100 times less active against aldehyde reductase, a related enzyme involved in the detoxification of reactive aldehydes.
5	15857120	The lead candidate, 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat, 9) inhibits aldose reductase with an IC(50) of 5 nM, while being 5400 times less active against aldehyde reductase, a related enzyme involved in the detoxification of reactive aldehydes.