Ignet

Gene Pair Information

Gene Pair: ALB, TGFB1

Related Sentences

#	PMID	Sentence
1	12677169	We demonstrate, for the first time, that glycated albumin activates RAW cell ERK and promotes ERK-dependent increases in TGF-beta(1) production, oxidative stress, and NF-kappa B activation.
2	17955662	The overgrowth of glomerulus, the excretion of beta2-MG in 24-hr urine, the albumin excretion rate in 24-hr urine and CCR in the HCT group significantly reduced (P<0.05), and the expression of TGF-beta1 and collagen I significantly decreased (P<0.05), but BMP-7 significantly increased (P<0.05) in the HCT group as compared with those in the model group, with no significant difference as compared with the lotensin group (P>0.05).
3	17018845	Glomerular cells in culture respond to albumin containing Amadori glucose adducts (the principal serum glycated protein), with activation of protein kinase C-beta(1), increased expression of transforming growth factor (TGF)-beta1, the TGF-beta type II signaling receptor, and the extracellular matrix proteins alpha(1)(IV) collagen and fibronectin and with decreased production of the podocyte protein nephrin.
4	20399741	Glycated albumin, an early-glycation Amadori-modified protein, stimulates transforming growth factor-beta (TGF-beta) expression and increases the production of the extracellular matrix proteins in mesangial cells, contributing to the pathogenesis of diabetic nephropathy.
5	20399741	Taken together, these data suggest that up-regulation of p47phox is involved in glycated albumin-mediated activation of NADPH oxidase, leading to glycated albumin-induced expression of TGF-beta and extracellular matrix proteins in mesangial cells and contributing to the development of diabetic nephropathy.