Ignet

Gene Pair: CBX4, INS

Related Sentences

#	PMID	Sentence
1	1478377	Cleavage of proinsulin is mediated by at least two prohormone convertases (PC3/PC1 and PC2).
2	8382698	The in vitro processing of mPOMC by the insulin secretory granule endopeptidase activity reported here is in excellent agreement with the in vivo processing of this prohormone by a combination of PC2 and PC3, candidates of prohormone endpeptidase, in gene transfer studies with cells that express the regulated secretory pathway (Thomas, L., Leduc, R., Thorne, B.
3	8138054	Both PC2 and PC3 activities are influenced by Ca2+ and pH, but the more stringent Ca2+ and pH requirements of PC3 suggest it as the most likely enzyme to regulate proinsulin conversion, as well as initiate it.