Ignet

Gene Pair Information

Gene Pair: CDKAL1, INS

Related Sentences

#	PMID	Sentence
1	18285412	Our objective was to investigate the impact of rs7754840 of CDKAL1 on insulin secretion, insulin sensitivity, and risk of type 2 diabetes.
2	18285412	In study 2, rs7754840 was significantly associated with type 2 diabetes (P = 0.022) and markers of impaired insulin release [insulinogenic index (IGI), P = 0.012] in 2405 men with normal glucose tolerance. rs7754840 of CDKAL1 was associated with markers of impaired insulin secretion in two independent studies.
3	18285412	Therefore, CDKAL1 is likely to increase the risk of type 2 diabetes by impairing insulin secretion.
4	19258404	In our cohort, only polymorphisms in SLC30A8, HHEX, TCF7L2, and CDKAL1 influenced insulin secretion.
5	19622614	The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion also reduce birth weight, and an association of low birth weight and the type 2 diabetes risk alleles at the HHEX-IDE and CDKAL1 loci were recently reported.
6	21151568	A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in ? cells is largely unknown.
7	21151568	Our results indicate that CDKAL1 controls first-phase insulin exocytosis in ? cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2+) channels through pathways other than CDK5-mediated regulation.
8	21841312	Mice with pancreatic ? cell-specific KO of Cdkal1 (referred to herein as ? cell KO mice) showed pancreatic islet hypertrophy, a decrease in insulin secretion, and impaired blood glucose control.