Ignet

Gene Pair Information

Gene Pair: EPO, AKT1

Related Sentences

#	PMID	Sentence
1	18473829	Erythropoietin controls a variety of signal transduction pathways during oxidative stress that can involve Janus-tyrosine kinase 2, protein kinase B, signal transducer and activator of transcription pathways, Wnt proteins, mammalian forkhead transcription factors, caspases, and nuclear factor kappaB.
2	19755525	Administration of erythropoietin (EPO) induced phosphorylation of Akt and GSK-3beta and reduced infarct size (% risk area) from 47.4 +/- 5.2% to 23.9 +/- 3.5% in LETO hearts.
3	19755525	However, neither phosphorylation of Akt and GSK-3beta nor infarct size limitation was induced by EPO in OLETF rats.
4	20981553	In hearts from healthy controls, EPO decreased infarct size (14.36��0.60 and 36.22��4.20% of left ventricle in EPO-treated and untreated hearts, respectively, p�<�0.05) and increased phosphorylated forms of Akt, ERK1/2, and their downstream target GSK-3?.
5	20981553	In hearts from STZ-induced diabetic rats, EPO did not decrease infarct size (32.05��2.38 and 31.88��1.87% in EPO-treated and untreated diabetic rat hearts, respectively, NS) nor did it increase phosphorylation of Akt, ERK1/2, and GSK-3?.
6	20981553	In contrast, in hearts from HFD-induced insulin resistance rats, EPO decreased infarct size (18.66��1.99 and 34.62��3.41% in EPO-treated and untreated HFD rat hearts, respectively, p�<�0.05) and increased phosphorylation of Akt, ERK1/2, and GSK-3?.
7	21443457	EPO also employs the activation of protein kinase B (Akt1) to foster phosphorylation of GSK-3? that appears required for EPO vascular protection.