Ignet

Gene Pair: GCG, PCSK2

Related Sentences

#	PMID	Sentence
1	17698597	Expression of PC1/3 rather than PC2 in alpha-cells induces GLP-1 and GLP-2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels and promotes islet survival.
2	21824269	As both Pcsk2(-/-) and Gcgr(-/-) mice exhibit increased production of glucagon-like peptide-1 (GLP-1), which is absent in Gcg(gfp/gfp), GLP-1 is the likely cause of the difference in metabolic impact of glucagon deficiency in these animal models.
3	21795304	Proglucagon is cleaved to glucagon by prohormone convertase 2 (PC2) in pancreatic ?-cells, but is cleaved to glucagon-like peptide-1 (GLP-1) by PC1 in intestinal L-cells.