Ignet

Gene Pair Information

Gene Pair: GHRL, LEP

Related Sentences

#	PMID	Sentence
1	11284421	The role of leptin in the appetite regulation in man is still not clear, other signalling molecules may have also an effect, e.g., ghrelin, which primarily stimulates STH secretion and brings about weight gain.
2	12663466	Whether the neurons that respond to ghrelin could be regulated by orexin and leptin was also examined.
3	12829648	The gastric peptide ghrelin augments and the adipocyte-derived hormone leptin reduces appetite and food intake.
4	12829648	Nondiabetic subjects were also studied during saline infusion, which did not affect ghrelin but decreased leptin by 19 +/- 6% (P < 0.03).
5	12829648	In control subjects, plasma ghrelin decreased at all clamp steps (-17 +/- 1, -27 +/- 6, and -33 +/- 4%, respectively; P < 0.006 vs. baseline), whereas leptin increased by 35 +/- 11% (P < 0.05).
6	12829648	In type 2 diabetic patients without insulin treatment, ghrelin decreased by 18 +/- 7% (P < 0.05) only after 4 mU x kg(-1) x min(-1) insulin infusion and leptin increased by 19 +/- 6% (P < 0.05).
7	15448083	When leptin signaling is reduced, as in the Zucker fatty rat, or when circulating ghrelin is increased during fasting, the effect of ghrelin becomes more dominant, indicating an influence of both hormones on ghrelin action.
8	15448083	These results show that the level of GHS-R expression in the ARC is reduced by leptin and increased by ghrelin and that the effect of ghrelin may be GH dependent.
9	19160571	Low ghrelin is associated with MS and type 2 diabetes in the presence of insulin and leptin resistance.
10	19876793	Leptin is an adipose-tissue derived peptide, circulating as free (fl) and receptor-bound protein (bl) acting antagonistically to ghrelin's effects on food intake.
11	19876793	In the present study we tested the weight dependent influence of an intravenous (i.v.) ghrelin injection on leptin levels as well as hepatic protein expression in healthy and endotoxemic rats.
12	21112019	Lack of sleep also down-regulates the satiety hormone leptin, up-regulates the appetite-stimulating hormone ghrelin, and increases hunger and food intake.
13	19745015	Also, the two TYJWT groups had lower serum levels of leptin compared to the control group, and the ghrelin levels were proportionately increased by the dosage of TYJWT given.
14	21676224	Fasting ghrelin decreased significantly while leptin, adiponectin and resistin remained unchanged.