Ignet

Gene Pair: HDAC4, MIRN206

Related Sentences

#	PMID	Sentence
1	21324893	We further demonstrate that TGF-? treatment of myogenic cells is associated with increased expression of histone deacetylase 4 (HDAC4), a key inhibitor of muscle differentiation that has been identified as a target for regulation by miR-206 and miR-29.
2	21324893	We confirmed that increased expression of miR-206 and miR-29 resulted in the translational repression of HDAC4 in the presence or absence of TGF-? via interaction with the HDAC4 3'-untranslated region.
3	21324893	Furthermore, we present evidence that the mechanism by which miR-206 and miR-29 can inhibit the TGF-?-mediated up-regulation of HDAC4 is via the inhibition of Smad3 expression, a transducer of TGF-? signaling.
4	21324893	These findings identify a novel mechanism of interaction between TGF-? and miR-206 and -29 in the regulation of myogenic differentiation through HDAC4.