Ignet

Gene Pair: HK2, INS

Related Sentences

#	PMID	Sentence
1	7883122	Hexokinase II (HKII) is the predominant hexokinase isozyme expressed in insulin-responsive tissues.
2	9519744	In response to 40 mU insulin, HKII mRNA in lean control subjects was increased 1.48 +/- 0.18-fold (P < 0.05) but failed to increase significantly in the obese (1.12 +/- 0.24) or NIDDM (1.14 +/- 0.18) groups.
3	9519744	In response to 240 mU insulin, HKII mRNA was increased in all groups (control subjects 1.48 +/- 0.18, P < 0.05 vs. basal, obese 1.30 +/- 0.16, P < 0.05, and NIDDM 1.25 +/- 0.14, P < 0.05).
4	9519744	Resistance to insulin's metabolic effects extends to its ability to induce HKII expression in obesity and NIDDM.
5	12410639	In L6 myotubes treated for 24 h with insulin there was increased expression of the HK isoform, HKII, and increased glucose phosphorylation without a concomitant increase in glucose transport, indirectly suggesting that phosphorylation of glucose was a target of insulin action [Osawa, Printz, Whitesell and Granner (1995) Diabetes 44, 1426-1432].