Ignet

Gene Pair: IAPP, CCL2

Related Sentences

#	PMID	Sentence
1	21589925	We found that MCP-1 induced amylin expression at transcriptional level and increased proamylin and intermediate forms of amylin at protein level in MIN6 cells and islets.
2	21589925	However, MCP-1 had no effect on the expressions of proinsulin 1 and 2, as well as prohormone convertase (PC) 1/3 and PC2, suggesting that MCP-1 specifically induces amylin expression in ?-cells.
3	21589925	Mechanistic studies showed that although there is no detectable CCR2 mRNA in MIN6 cells and islets, pretreatment of MIN6 cells with pertussis toxin inhibited MCP-1 induced amylin expression, suggesting that alternative Gi-coupled receptor(s) mediates the inductive effect of MCP-1.
4	21589925	These results suggest that MCP-1 induces murine amylin expression through AP1 activation mediated by ERK1/2 or JNK.
5	21589925	MCP-1 induces amylin expression through ERK1/2/JNK-AP1 and NF-?B related signaling pathways independent of CCR2.
6	21589925	Amylin upregulation by MCP-1 may contribute to elevation of plasma amylin in obesity and insulin resistance.