Ignet

Gene Pair: IL1B, PTGS2

Related Sentences

#	PMID	Sentence
1	9465095	Basal and IL-1-stimulated prostaglandin E2 synthesis were blocked by a specific COX-2 inhibitor.
2	9465095	IL-1 stimulation had a biphasic effect on COX-2 mRNA levels with an initial mild increase at 2-4 hr followed by a more dramatic decrease below basal level by 24 hr.
3	9465095	The IL-1-induced increase in COX-2 mRNA levels was accompanied by a parallel increase in NF-kappaB binding to COX-2 promoter elements.
4	9568691	IL-1beta also induces the coexpression of the inducible isoform of cyclooxygenase (COX-2) that results in the overproduction of proinflammatory prostaglandins.