Ignet

Gene Pair Information

Gene Pair: INS, LIPE

Related Sentences

#	PMID	Sentence
1	7476323	This study was designed to examine the effects of insulin deficiency on the regulation of HSL in isolated adipocytes.
2	7476323	Compared with levels in control rats, 10 days of insulin deficiency increased HSL activity twofold (P < .05), as assayed for neutral cholesterol esterase activity, and insulin treatment returned HSL activity to normal.
3	7476323	In conclusion, our studies suggest that 10 days of insulin deficiency increases HSL expression via pretranslational mechanisms and short-term insulin treatment returns HSL activity to normal via posttranslational mechanisms in adipose tissue.
4	12200416	However, in the presence of high glucose both insulin and leptin caused a significant increase in the activity of acyl-CoA: cholesterol O-acyltransferase (ACAT) combined with a significant reduction in the level of hormone-sensitive lipase (HSL).
5	12200416	This contrasts with 3T3-L1 adipocytes, where HSL activity and expression are increased by insulin in high glucose conditions.
6	15255786	CON. (2) Acute or chronic nateglinide treatment induced a prompt increase in prandial insulin secretion, resulting in a decrease in blood glucose and NEFA levels owing to suppression of HSL, while BF, LPL and TAG clearance remained suppressed.
7	15701680	To determine the metabolic role of HSL, we examined the changes in tissue-specific insulin action and glucose metabolism in vivo during hyperinsulinemic euglycemic clamps after 3 wk of high-fat or normal chow diet in awake, HSL-deficient (HSL-KO) mice.
8	15887043	Exposure to rosiglitazone for 24 h induced ucp-1, lpl and hsl gene expression and when rosiglitazone was combined with insulin a synergistic effect on lpl and ucp-3 mRNA expression was produced.
9	21216462	MTII treatment also significantly reduced expression levels of hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) mRNA in white adipose tissue of diabetic mice without a significant change in serum insulin levels.
10	21498783	We hypothesized that an imbalance of ATGL relative to HSL (expression or activity) may contribute to DAG accumulation and insulin resistance.
11	21498783	We show that selective HSL inhibition induces DAG accumulation and insulin resistance.
12	21498783	Altogether, the data indicate that altered ATGL and HSL expression in skeletal muscle could promote DAG accumulation and disrupt insulin signaling and action.
13	20957006	The level of fasting insulin was higher in OLETF rats than that of LETO rats only at the age of 28 weeks [(68.17�13.35)�10(-3) vs (19.61�0.20)�10(-3) U/L, P<0.01]. (2) Glycerol released from epididymal adipose tissues of OLETF rats was increased by 34.7% compared with LETO rats at the age of 18 weeks [(213.0�12.5) vs (158.2�11.7) nmol/(g�h), P<0.05], whereas at the age of 28 weeks, it was reduced by 33.5% [(210.2�37.8) vs (315.9�25.0) nmol/(g�h), P<0.05]. (3) In OLETF rats, HSL protein level was not altered at the age of 18 weeks, but down-regulated at the age of 28 weeks.
14	17684441	We showed that insulin inhibited beta-agonist-induced lipolysis at least in part by inhibiting phosphorylation of perilipin and hormone-sensitive lipase (HSL) in 3T3-L1 adipocytes.