Ignet

Gene Pair: INS, SPP1

Related Sentences

#	PMID	Sentence
1	16293771	Twenty-four hours after STZ injection, the intensified OPN expression was localized towards the periphery of the islets and surrounded the remaining insulin-positive cells.
2	20107108	Here, we studied OPN effects in obesity-induced inflammation and insulin resistance by targeting OPN action in vivo.
3	20107108	Moreover, we report OPN as a novel negative regulator for the activation of hepatic signal transducer and activator of transcription 3 (STAT3), which is essential for glucose homeostasis and insulin sensitivity.
4	20107108	These findings demonstrate that antibody-mediated neutralization of OPN action significantly reduces insulin resistance in obesity.
5	20107108	OPN neutralization partially decreases obesity-associated inflammation in adipose tissue and liver and reverses signal transduction related to insulin resistance and glucose homeostasis.
6	21562757	The cytokine osteopontin (OPN) was recently shown to be involved in obesity-induced adipose tissue inflammation and reduced insulin response.
7	21810601	In addition, OPN stimulated cell proliferation in insulin-secreting cells.