Ignet

Gene Pair: KLK3, JAK2

Related Sentences

#	PMID	Sentence
1	15378031	A newly developed bridging yeast tri-hybrid assay showed that APS dimerizes JAK2, insulin receptor and IGF1 receptor kinases using its SH2 and dimerization domains.
2	15767667	At lower levels of SH2-B or APS expression, dimerization approximates two JAK2 molecules to induce transactivation.
3	15767667	SH2-B or APS homodimerization and SH2-B/APS heterodimerization thus provide direct mechanisms for activating and inhibiting JAK2 and other kinases from the inside of the cell and for potentiating or attenuating cytokine and growth factor receptor signaling when ligands are present.