Ignet

Gene Pair: LEP, BCL2

Related Sentences

#	PMID	Sentence
1	17318810	This study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators B-cell leukaemia 2 gene product (BCL-2) and BCL2-associated X protein (Bax) in the glucose-responsive BRIN-BD11 beta-cell line.
2	17318810	At the protein level, leptin increased BCL-2 and decreased Bax, altering the BCL-2 : Bax ratio.
3	17318810	We conclude that leptin reduces apoptosis in beta-cells at physiological concentrations, possibly via its ability to up-regulate BCL-2 and Bax expression.