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Gene Pair: PDX1, ATF3

Related Sentences

#	PMID	Sentence
1	21821004	Both thapsigargin treatment, an inducer of ER stress, and ATF3 expression decreased PDX-1 expression in pancreatic ?-cells, MIN6N8.
2	21986529	Previously, we showed that ATF3 downregulates PDX-1 gene expression in MIN6N8 pancreatic ?-cells.
3	21986529	Here, we investigated another role of ATF3 on the regulation of PDX-1 activity.
4	21986529	ATF3 significantly inhibited PDX-1-stimulated transactivation of reporter plasmid containing promoters for PDX-1 binding element and the PDX-1 target gene glucokinase, which is dependent on C-terminal domain of ATF3.
5	21986529	ATF3 interacted with PDX-1, and effectively inhibited p300-mediated transcriptional coactivation of the PBE-containing promoter, whereas C-terminal domain-deleted ATF3 did not inhibit the transcoactivation of p300.
6	21986529	Taken together, these results suggest that ATF3 inhibits PDX-1-mediated transactivation through the inhibition of p300-stimulated coactivation, which may lead to ?-cell dysfunction by ER stress.