Ignet

Gene Pair: PRKD1, ADIPOQ

Related Sentences

#	PMID	Sentence
1	21345437	We therefore investigated the involvement of PKD in regulation of the adiponectin gene expression.
2	21345437	Knockdown of PKD by its siRNA led to the increase in the mRNA and the promoter activity of adiponectin, and resulted in increase of adiponectin secretion and decrease of fat accumulation in cultured cells.
3	21345437	PKD activators decreased expression of the adiponectin gene, and its inhibition by PKD siRNA and by a selective inhibitor G�6983 canceled this effect.
4	21345437	ChIP analysis demonstrated that inhibition of PKD activity decreased the DNA binding of AP-2? to the adiponectin promoter.
5	21345437	PKD is thus a common modulator of the DNA binding activity of AP-2? and AP-2? through their phosphorylation for negative regulation of the ABCA1 and adiponectin genes expression, respectively.