Ignet

Gene Pair: SERPINF1, CD40LG

Related Sentences

#	PMID	Sentence
1	19237211	Although there is a growing body of evidence that inhibition of platelet CD40 ligand (CD40L) expression may be a novel therapeutic target for preventing CVD, effects of PEDF on platelet CD40L expression remain to be elucidated.
2	19237211	In this study, we examined the effects of PEDF administration on platelet CD40L expression in diabetic or AGE-injected non-diabetic rats.
3	19237211	Further, AGE injection to non-diabetic rats was found to increase platelet CD40L expression levels by about 1.3-folds, whose effects were completely prevented by the treatment with PEDF.
4	19237211	Our present study suggests that PEDF could inhibit platelet CD40L overexpression in diabetes by blocking the effects of AGEs on platelets.