Ignet

Gene Pair: WFS1, INS

Related Sentences

#	PMID	Sentence
1	11181571	Wolfram (DIDMOAD) syndrome is an autosomal recessive neurodegenerative disorder accompanied by insulin-dependent diabetes mellitus and progressive optic atrophy.
2	15994758	Homozygous WFS1 gene mutations cause Wolfram syndrome, characterized by insulin-deficient diabetes mellitus and optic atropy.
3	19190890	We studied the effect of breeding Wfs1 ( -/- ) mice on a C57BL/6J background with mild obesity and insulin resistance, by introducing the agouti lethal yellow mutation (A ( y ) /a).
4	19330314	We aimed to investigate the effect of a common WFS1 single-nucleotide polymorphism on several aspects of insulin secretion.
5	19258404	We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity.
6	20802253	For the SNPs in TCF7L2 and WFS1, we found a significant interaction between glucose control and insulin secretion (all P ? 0.0018 for glucose � genotype).
7	20802253	For the diabetes risk genes TCF7L2 and WFS1, which are associated with impaired incretin signaling, the level of glycemia determines SNP effects on insulin secretion.
8	21127832	We investigated associations of allelic variations in the WFS1 gene with insulin secretion and risk of type 2 diabetes in a general population prospective study.