Gene Information
Gene symbol: MSH6
Gene name: mutS homolog 6 (E. coli)
HGNC ID: 7329
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATM | 1 hits |
| 2 | BLM | 1 hits |
| 3 | BRCA1 | 1 hits |
| 4 | BRCA2 | 1 hits |
| 5 | CHEK2 | 1 hits |
| 6 | MLH3 | 1 hits |
| 7 | MSH2 | 1 hits |
| 8 | NBN | 1 hits |
| 9 | PALB2 | 1 hits |
| 10 | PMS2 | 1 hits |
| 11 | PTEN | 1 hits |
| 12 | RAD50 | 1 hits |
| 13 | RBM10 | 1 hits |
| 14 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 33426465 | Patients (N=37 349) had RS results of whom 714 had <i>BRCA1</i>, <i>BRCA2</i>, <i>CHEK2</i>, <i>ATM</i>, <i>PALB2</i>, or Lynch syndrome (<i>MLH1</i>, <i>MSH2</i>, <i>MSH6</i>, <i>PMS2</i>) PVs. |
| 2 | 33426465 | For women aged 50 years or older at breast cancer diagnosis, RS often exceeded the chemotherapy benefit threshold (≥26) with <i>BRCA1</i> (71.7% vs 14.4% with none; <i>P</i> <.001), <i>PALB2</i> (37.1%; <i>P</i> = .001), and <i>BRCA2</i> (44.3%; <i>P</i> < .001) PVs. |
| 3 | 33426465 | PVs in <i>BRCA1</i>, but not <i>BRCA2</i>, <i>PALB2</i>, <i>ATM</i>, <i>CHEK2</i>, or Lynch syndrome genes, were associated with elevated RS on multivariable analysis (<i>P</i> < .001). |
| 4 | 34933735 | Also, MLH3 is a DNA mismatch repair gene and mutation in this gene is harmful in different cancers. |
| 5 | 34933735 | We identified 26 variants in breast cancer patients, 22 inherited variants were found in MLH3, CHECK2, BRCA1, BRCA2, BLM, TP53, MSH6, NBN and PTEN genes and 4 somatic variants were found in PALB2, RAD50 and RBM10 genes. |