Gene Information
Gene symbol: MYC
Gene name: v-myc myelocytomatosis viral oncogene homolog (avian)
HGNC ID: 7553
Synonyms: c-Myc, bHLHe39
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTB | 1 hits |
| 2 | AKT1 | 1 hits |
| 3 | BRCA1 | 1 hits |
| 4 | BRCA2 | 1 hits |
| 5 | EXO1 | 1 hits |
| 6 | FOXM1 | 1 hits |
| 7 | PIK3CA | 1 hits |
| 8 | RAD51 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10375022 | To understand the mechanism underlying the inhibition of proliferation by estradiol, we examined the expression of several growth related endogenous genes. c-Myc protooncogene expression was strongly inhibited by treatment with estradiol as was expression of BRCA1 and BRCA2 genes, which is in agreement with their mitogenic-dependent expression, while expression of beta-actin, a housekeeping gene, was not affected by hormone treatment. |
| 2 | 33513753 | Using peripheral blood mononuclear cells (PBMCs) of these two affected family members and two normal (BRCA1+/+) individuals, we established a number of iPSC clones via non-integrating Sendai virus-based delivery of the four OCT4, SOX2, KLF4, and c-MYC factors. |
| 3 | 33513753 | In transcriptome analyses, BRCA1+/- iMSCs exhibited a unique pro-angiogenic signature: compared to non-mutated iMSCs, they expressed high levels of HIF-1α, angiogenic factors belonging to the VEGF, PDGF, and ANGPT subfamilies showing high angiogenic potential. |
| 4 | 33513753 | We also reported a highly increased migration capacity of BRCA1+/- iMSCs through an in vitro wound healing assay that correlated with the upregulation of the periostin (POSTN). |
| 5 | 33637776 | BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. |
| 6 | 33637776 | Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. |
| 7 | 33637776 | Phosphoinositide 3-kinase (PI3K) inhibition sensitizes BRCA-proficient TNBC to PARP inhibition, which broadens the indication of PARP inhibitors. |
| 8 | 33637776 | Previously researches have reported that PI3K inhibition induced the defect of homologous recombination (HR) mediated repair by downregulating the expression of BRCA1/2 and Rad51. |
| 9 | 33637776 | Herein, we focused on DNA damage, DNA single-strand breaks (SSBs) repair and DNA double-strand breaks (DSBs) repair three aspects to investigate the mechanism of dual PI3K and PARP inhibition in DNA damage response. |
| 10 | 33637776 | We found that dual PI3K and PARP inhibition with BKM120 and olaparib significantly reduced the proliferation of BRCA-proficient TNBC cell lines MDA-MB-231 and MDA231-LM2. |
| 11 | 33637776 | Olaparib resulted in concomitant gain of PARP1, forkhead box M1 (FOXM1) and Exonuclease 1 (Exo1) while inhibited the activity of PARP. |
| 12 | 33637776 | BKM120 downregulated the expression of PARP1 and PARP2 to assist olaparib in blocking PARP mediated repair of DNA SSBs. |
| 13 | 33637776 | Meanwhile, BKM120 inhibited the expression of BRAC1/2 and Rad51/52 to block HR mediated repair through the PI3K/Akt/NFκB/c-Myc signaling pathway and PI3K/Akt/ FOXM1/Exo1 signaling pathway. |
| 14 | 33637776 | FOXM1 and Exo1 are novel therapeutic targets that serves important roles in DNA damage response. |