Gene Information
Gene symbol: RNF19A
Gene name: ring finger protein 19A, E3 ubiquitin protein ligase
HGNC ID: 13432
Synonyms: dorfin, DKFZp566B1346
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BARD1 | 1 hits |
| 2 | BRCA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 34789768 | RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. |
| 2 | 34789768 | RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. |
| 3 | 34789768 | Dysfunction of the BRCA1 pathway enhances the therapeutic efficiency of poly-(ADP-ribose) polymerase inhibitors (PARPi) in cancers, but the molecular mechanisms underlying this sensitization to PARPi are not fully understood. |
| 4 | 34789768 | Dysfunction of the BRCA1 pathway enhances the therapeutic efficiency of poly-(ADP-ribose) polymerase inhibitors (PARPi) in cancers, but the molecular mechanisms underlying this sensitization to PARPi are not fully understood. |
| 5 | 34789768 | We demonstrate that RNF19A suppresses HR by ubiquitinating BARD1, which leads to dissociation of BRCA1-BARD1 complex and exposure of a nuclear export sequence in BARD1 that is otherwise masked by BRCA1, resulting in the export of BARD1 to the cytoplasm. |
| 6 | 34789768 | We demonstrate that RNF19A suppresses HR by ubiquitinating BARD1, which leads to dissociation of BRCA1-BARD1 complex and exposure of a nuclear export sequence in BARD1 that is otherwise masked by BRCA1, resulting in the export of BARD1 to the cytoplasm. |