Gene Information
Gene symbol: BCL2
Gene name: B-cell CLL/lymphoma 2
HGNC ID: 990
Synonyms: Bcl-2, PPP1R50
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCNA2 | 1 hits |
| 2 | CDKN1B | 1 hits |
| 3 | CHKA | 1 hits |
| 4 | FAS | 1 hits |
| 5 | FASLG | 1 hits |
| 6 | MKI67 | 1 hits |
| 7 | PSMD9 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9811343 | To determine the relationship between cell cycle regulation and differentiation, the spatiotemporal expression of cyclin A, cyclin B1, cyclin D1, the cyclin-dependent kinase inhibitors (CKIs) p27 and p57, and markers of differentiating podocytes in developing human kidneys was investigated by immunohistochemistry. |
| 2 | 9811343 | In S-shaped body stage, Ki-67, a cell proliferation marker that labels the G1/S/G2/M phase, was expressed in the majority (more than 80%) of presumptive podocytes, along with cyclin A (approximately 20% of the Ki-67-positive cells) and cyclin B1 (less than 5% of Ki-67-positive cells) expression. |
| 3 | 9811343 | Among these cells), cyclin D1 and CKIs were markedly down-regulated. |
| 4 | 9811343 | At the capillary-loop stage, by contrast, CKIs and cyclin D1 were intensely positive in podocytes, whereas no Ki-67, cyclin B1, or cyclin A expression was seen. |
| 5 | 9811343 | Moreover, double-immunolabeling and serial-section analysis provided evidence that CKIs and markers specific for differentiating podocytes, namely PHM-5 (podocalyxin-like protein in humans), synaptopodin (a foot process-related protein), and C3b receptor, were co-expressed at the capillary-loop stage. |
| 6 | 9811343 | Furthermore, bcl-2 (an apoptosis inhibitory protein) showed a reciprocal expression pattern to that of CKI. |
| 7 | 10526006 | Additionally, serial section analysis revealed that Ki-67-positive cells in the crescents were frequently cyclin-A positive and Bcl-2 positive, but seldom cyclin-B(1) positive. |
| 8 | 10526006 | Additionally, serial section analysis revealed that Ki-67-positive cells in the crescents were frequently cyclin-A positive and Bcl-2 positive, but seldom cyclin-B(1) positive. |
| 9 | 10526006 | Moreover, the expression of cyclin-dependent kinase inhibitor p27(Kip1) was low in the cellular crescents, despite being exclusively positive in podocytes within the same section. |
| 10 | 10526006 | Moreover, the expression of cyclin-dependent kinase inhibitor p27(Kip1) was low in the cellular crescents, despite being exclusively positive in podocytes within the same section. |
| 11 | 10526006 | We concluded that the major component of the cellular crescents is made up of PECs and that apparent expression of cyclins and Bcl-2 and restrained expression of p27(Kip1) may be synergistically associated with the development of cellular crescents in human CRGN. |
| 12 | 10526006 | We concluded that the major component of the cellular crescents is made up of PECs and that apparent expression of cyclins and Bcl-2 and restrained expression of p27(Kip1) may be synergistically associated with the development of cellular crescents in human CRGN. |
| 13 | 11141501 | Hepatocyte growth factor, but not insulin-like growth factor I, protects podocytes against cyclosporin A-induced apoptosis. |
| 14 | 11141501 | Cyclosporin A (CsA) nephropathy is associated with altered expression of apoptosis regulatory genes such as Fas-ligand and Bcl-2 family members in the glomerular, tubulointerstitial, and vascular compartments. |
| 15 | 11141501 | Both hepatocyte growth factor (HGF) and insulin-like growth factor (IGF-I) protect against apoptosis, and HGF specifically up-regulates Bcl-xL, a protein that regulates apoptosis. |
| 16 | 11141501 | We investigated whether Bcl-xL and Fas/Fas-ligand were regulated by CsA in cultured podocytes and whether CsA-induced apoptosis was prevented by HGF or IGF-I. |
| 17 | 11141501 | A murine podocyte cell line was treated with CsA in the presence or absence of HGF or IGF-I. |
| 18 | 11141501 | Apoptosis was quantitated by ELISA and by flow cytometry; Bcl-xL, Fas, and Fas-ligand were measured by Western blotting. |
| 19 | 11141501 | Inhibitors of MAP kinase/ERK kinase (MEK)-1 and of phosphatidylinositol 3'-kinase (PI3'-K) were used to determine the signaling pathways involved in Bcl-xL regulation. |
| 20 | 11141501 | HGF, but not IGF-I, prevented apoptosis and restored Bcl-xL levels. |
| 21 | 11141501 | The regulation of Bcl-xL by HGF was mediated by the PI3'-K but not by the MEK-1 pathway. |
| 22 | 11141501 | Apoptosis was prevented by pretreatment with HGF but not IGF-I. |