Gene Information
Gene symbol: ABCB1
Gene name: ATP-binding cassette, sub-family B (MDR/TAP), member 1
HGNC ID: 40
Synonyms: P-gp, CD243, GP170, ABC20
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC1 | 1 hits |
| 2 | HLA-A | 1 hits |
| 3 | IL2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9378159 | Highly expressed oncogenes such as bcl-2, HER2/neu and others or mutated suppressor genes such as p53 or BRCA1 have been characterised as hereditary susceptibility genes leading to syndromes such as breast/ovarian cancer syndrome, Li-Fraumeni and others. |
| 2 | 9378159 | Furthermore efflux-genes such as MDR-1 or MRP can be circumvented, suicide-genes can be employed which can facilitate sensitivity by encoding enzymes capable of converting inactive forms of a drug into toxic antimetabolites and immunotherapy can be achieved, by transfection of tumour cells with adenoviral vectors encoding immunomodulators such as IL-2 or MHC molecules. |