Gene Information
Gene symbol: AR
Gene name: androgen receptor
HGNC ID: 644
Synonyms: AIS, NR3C4, SMAX1, HUMARA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRCA1 | 1 hits |
| 2 | ESR1 | 1 hits |
| 3 | MLH1 | 1 hits |
| 4 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8013003 | Four genes are now known to be responsible for inherited susceptibility to breast cancer: the BRCA1 gene on chromosome 17q21, the ataxia-telangiectasia (AT) gene (11q22-q23), the TP53 gene (17p13.1) and the androgen receptor (AR) (Xq11.2-q12). |
| 2 | 8085754 | Three genes involved in the genetic predisposition to breast tumors have recently been identified: BRCA-1 associated with early onset familial breast cancer and breast/ovarian carcinoma syndrome, p53 associated with Li-Fraumeni syndrome, and the androgen receptor gene in male breast cancer with Reinfenstein syndrome. |
| 3 | 8364930 | Three loci have been implicated in the etiology of familial breast cancer; the BRCA1 locus on 17q, the p53 gene on 17p, and the androgen receptor gene on the X chromosome. |
| 4 | 8541881 | An estimated 5 to 10% of all breast and ovarian cancer is attributable to inherited mutations in two highly penetrant autosomal dominant susceptibility genes, BRCA1 and BRCA2. |
| 5 | 8541881 | BRCA1 confers higher risk of ovarian cancer and BRCA2 much higher risk of male breast cancer. |
| 6 | 8541881 | At least two other genes, P53 and the androgen receptor, are responsible for inherited predisposition to breast cancer in rare families. |
| 7 | 8695152 | The TP53 gene is involved in breast cancer development in the Li-Fraumeni syndrome and Li-Fraumeni syndrom-like families, whereas germ-line mutations in the androgen receptor (AR) gene is present in a subset of male breast cancers. |
| 8 | 10030809 | Recent advances in molecular biology, however, have shown that hereditary breast cancer may eventuate as a result of mutations on several specific gene loci including BRCA1, BRCA2, ATM gene, PTEN and p53. |
| 9 | 10030809 | Several other less frequently occurring predisposition genes such as the androgen receptor gene (AR), the HNPCC genes and the oestrogen receptor gene may also be involved, but to a lesser extent. |
| 10 | 10030809 | Overall, approximately 5-10% of all breast cancers are thought to involve one of these inherited predisposition genes, with BRCA1 and BRCA2 being responsible for as much as 90% of this group. |
| 11 | 10205268 | Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat. |