Gene Information
Gene symbol: BAX
Gene name: BCL2-associated X protein
HGNC ID: 959
Synonyms: BCL2L4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2 | 1 hits |
| 2 | BRCA1 | 1 hits |
| 3 | BRCA2 | 1 hits |
| 4 | CDKN1A | 1 hits |
| 5 | EP300 | 1 hits |
| 6 | MDM2 | 1 hits |
| 7 | TGFBR2 | 1 hits |
| 8 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9662340 | As compared with parental cells and vector transfected clones, wtBRCA1 clones exhibited: (1) a slightly decreased proliferation rate (doubling time = 25 h as compared with 22 h for control cells); (2) a (3-6)-fold increase in sensitivity to chemotherapy drugs (adriamycin, camptothecin, and taxol); (3) increased susceptibility to drug-induced apoptosis; (4) reduced repair of single-strand DNA strand breaks; and (5) alterations in expression of key cellular regulatory proteins (including BRCA2, p300, Mdm-2, p21(WAF1/CIP1), Bcl-2 and Bax). |
| 2 | 9796697 | p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours. |
| 3 | 9796697 | The status of p53 was investigated in breast tumours arising in germ-line carriers of mutant alleles of BRCA1 and BRCA2 and in a control series of sporadic breast tumours. p53 expression was detected in 20/26 (77%) BRCA1-, 10/22 (45%) BRCA2-associated and 25/72 (35%) grade-matched sporadic tumours. |
| 4 | 9796697 | Analysis of additional genes, p16INK4, Ki-ras and beta-globin revealed absence or very low incidence of mutations, suggesting that the higher frequency of p53 mutation in the BRCA-associated tumours does not reflect a generalized increase in susceptibility to the acquisition of somatic mutation. |
| 5 | 9796697 | Furthermore, absence of frameshift mutations in the polypurine tracts present in the coding sequence of the TGF beta type II receptor (TGF beta IIR) and Bax implies that loss of function of BRCA1 or BRCA2 does not confer a mutator phenotype such as that found in tumours with microsatellite instability (MSI). p21Waf1 was expressed in BRCA-associated tumours regardless of p53 status and, furthermore, some tumours expressing wild-type p53 did not express detectable p21Waf1. |