Gene Information
Gene symbol: DLG4
Gene name: discs, large homolog 4 (Drosophila)
HGNC ID: 2903
Synonyms: PSD-95, PSD95, SAP90, SAP-90
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MPP2 | 1 hits |
| 2 | TJP1 | 1 hits |
| 3 | TJP2 | 1 hits |
| 4 | TNFRSF1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7590743 | These conserved regions are shared among members of the discs-large family of proteins that include human p55, a membrane protein expressed in erythrocytes, rat PSD-95/SAP90, a synapse protein expressed in brain, Drosophila dIg-A, a septate junction protein expressed in various epithelia, and human and mouse ZO-1 and canine ZO-2, two tight junction proteins. dIg-A has been shown to act as a tumor suppressor, and the other members may all be involved in signal transduction through specialized membrane domains with highly organized cytoskeletons and thus are potential tumor suppressors. |
| 2 | 7590743 | Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors. |