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Gene Information

Gene symbol: IGF1

Gene name: insulin-like growth factor 1 (somatomedin C)

HGNC ID: 5464

Synonyms: IGF1A

Related Genes

# Gene Symbol Number of hits
1 AAVS1 1 hits
2 ACTB 1 hits
3 BRCA1 1 hits
4 CD44 1 hits
5 CDKN1C 1 hits
6 CSF1 1 hits
7 DDIT3 1 hits
8 DYNC1H1 1 hits
9 EGF 1 hits
10 FOS 1 hits
11 GPR180 1 hits
12 HIST1H2BO 1 hits
13 HIST2H2BE 1 hits
14 HSPG2 1 hits
15 IGFALS 1 hits
16 IGFBP2 1 hits
17 IGFBP4 1 hits
18 IL2 1 hits
19 INS 1 hits
20 MDK 1 hits
21 MLLT3 1 hits
22 PSEN2 1 hits
23 SLC9A3R2 1 hits
24 SMARCA1 1 hits
25 TP63 1 hits

Related Sentences

# PMID Sentence
1 7507078 The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer.
2 7507078 The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity.
3 7507078 Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1.
4 7507078 IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015.
5 7507078 IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1.
6 9010238 Four lines of evidence lead us to conclude that E2 induces BRCA1 primarily through an increase in DNA synthesis: (1) The kinetics and magnitude of induction are different from the directly E2 inducible gene, pS2; (2) Induction of BRCA1, but not pS2, is blocked by cycloheximide indicating that de novo protein synthesis is required; (3) Other hormonal and growth factor treatments that induce DNA synthesis have a similar effect, including IGF-1, EGF and DNA synthetic flares induced by tamoxifen and retinoic acid; (4) BRCA1 genomic fragments near the 5' end of the gene containing putative estrogen response elements fail to respond to E2 when transfected into breast cancer cell lines.
7 9032395 The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.
8 9032395 We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1).