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Gene Information

Gene symbol: IL2

Gene name: interleukin 2

HGNC ID: 6001

Synonyms: IL-2, TCGF

Related Genes

# Gene Symbol Number of hits
1 AAVS1 1 hits
2 ABCB1 1 hits
3 ABCC1 1 hits
4 ACTB 1 hits
5 BRCA1 1 hits
6 CD44 1 hits
7 CDKN1C 1 hits
8 CSF1 1 hits
9 DDIT3 1 hits
10 DYNC1H1 1 hits
11 FOS 1 hits
12 GPR180 1 hits
13 HIST1H2BO 1 hits
14 HIST2H2BE 1 hits
15 HLA-A 1 hits
16 HSPG2 1 hits
17 IGF1 1 hits
18 IGFALS 1 hits
19 IGFBP2 1 hits
20 INS 1 hits
21 MDK 1 hits
22 MLLT3 1 hits
23 SLC9A3R2 1 hits
24 SMARCA1 1 hits
25 TP63 1 hits

Related Sentences

# PMID Sentence
1 9032395 The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.
2 9032395 We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1).
3 9378159 Highly expressed oncogenes such as bcl-2, HER2/neu and others or mutated suppressor genes such as p53 or BRCA1 have been characterised as hereditary susceptibility genes leading to syndromes such as breast/ovarian cancer syndrome, Li-Fraumeni and others.
4 9378159 Furthermore efflux-genes such as MDR-1 or MRP can be circumvented, suicide-genes can be employed which can facilitate sensitivity by encoding enzymes capable of converting inactive forms of a drug into toxic antimetabolites and immunotherapy can be achieved, by transfection of tumour cells with adenoviral vectors encoding immunomodulators such as IL-2 or MHC molecules.