Gene Information
Gene symbol: MRE11A
Gene name: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
HGNC ID: 7230
Synonyms: ATLD
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NBN | 1 hits |
| 2 | RAD50 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10362364 | Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. |
| 2 | 10362364 | Association of breast tumor susceptibility gene products BRCA1 and BRCA2 with the RAD51 recombination protein suggested that cancer could arise through defects in recombination. |
| 3 | 10362364 | The identification of NBS1, responsible for Nijmegen breakage syndrome, from the MRE11/RAD50 recombination protein complex also supports this hypothesis. |
| 4 | 10362364 | These findings suggest that RAD54B may play an active role in recombination processes in concert with other members of the RAD52 epistasis group. |
| 5 | 10362365 | Association of a recombinational repair protein RAD51 with tumor suppressors BRCA1 and BRCA2 suggests that defects in homologous recombination are responsible for tumor formation. |
| 6 | 10362365 | Also recent findings that a protein associated with the MRE11/RAD50 repair complex is mutated in Nijmegen breakage syndrome characterized by increased cancer incidence and ionizing radiation sensitivity strongly support this idea. |
| 7 | 10362365 | Since RAD51 forms a complex with other members of the RAD52 epistasis group and with BRCA proteins, it is reasonable to ask if alterations of members of the RAD52 epistasis group lead to tumor development. |