Gene Information
Gene symbol: MSH2
Gene name: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
HGNC ID: 7325
Synonyms: HNPCC, HNPCC1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRCA1 | 1 hits |
| 2 | BRCA2 | 1 hits |
| 3 | MLH1 | 1 hits |
| 4 | MSH3 | 1 hits |
| 5 | MSH6 | 1 hits |
| 6 | PMS1 | 1 hits |
| 7 | PMS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7987639 | Amongst the important known susceptibility genes are those dominant genes conferring a high risk of breast and ovarian cancer (BRCA1), colon cancer (hMSH2 and hMLH1), and melanoma (MLM). |
| 2 | 8573439 | Recently, a second class of susceptibility genes, mismatch repair genes such as MSH2 and MLH1, has been shown to be defective in hereditary nonpolyposis colon cancers. |
| 3 | 8678487 | For example, hMSH2 and hMLH1, which are known as DNA mismatch repair genes have been found to cause HNPCC (hereditary non-poliposis colorectal cancer). |
| 4 | 8678487 | BRCA1 and BRCA2 are tumor suppressor genes that have recently been identified as familial breast and ovarian cancer, familial breast cancer genes. |
| 5 | 9534190 | The breast and ovarian cancer syndrome is linked to the BRCA1 gene on chromosome 17q and, to a lesser extent, to the BRCA2 gene on chromosome 13q. |
| 6 | 9534190 | The HNPCC syndrome is caused by any one of three known genes, hMSH2, hMLH1, and hPMS2, that encode proteins involved in the same pathway of DNA mismatch repair. |
| 7 | 9534190 | Current research challenges include elucidating these modifying factors, gaining a better understanding of the biological function of BRCA1 and BRCA2 products, and determining the appropriate clinical intervention for genetically predisposed patients. |
| 8 | 9538124 | Studies have shown that these diseases may be associated with mutations in a number of tumor suppressor genes, mainly BRCA1 and BRCA2. |
| 9 | 9538124 | HNPCC-ovarian cancer associated families reveal frequent mutations in at least four genes (hMSH2, hMLH1, hPMS1, and hPMS2) involved in the repair of mismatched DNA. |
| 10 | 9633840 | An important recent advancement in the field of ovarian cancer research is the identification of the breast/ovarian cancer susceptibility genes, BRCA1 and BRCA2. |
| 11 | 9633840 | A second class of genes involved in DNA mismatch repair (MMR) are responsible for most cases of hereditary nonpolyposis colorectal cancer (HNPCC). |
| 12 | 9633840 | Individuals in cancer-prone kindreds are currently being screened for germline mutations in BRCA1, BRCA2, and several MMR genes (eg, MSH2, MLH1), and mutant allele carriers counseled for cancer risks. |
| 13 | 9633840 | Although BRCA1, BRCA2, and a number of MMR genes have been identified, many more genes involved in gynecologic malignancies remain to be discovered and the clinical significance of the cancer genes already known is still in its infancy. |
| 14 | 10388122 | The most noteworthy hereditary gynecologic cancer syndromes include hereditary breast-ovarian cancer (HBOC) syndrome, wherein BRCA1 and BRCA2 germ-line mutations have been identified, and hereditary nonpolyposis colorectal cancer (HNPCC) of the Lynch syndrome II variant, wherein hMSH2, hMLH1, hPMS2, hMSH3, and hMSH6 germ-line mutations have been identified. |