Gene Information
Gene symbol: PSEN2
Gene name: presenilin 2 (Alzheimer disease 4)
HGNC ID: 9509
Synonyms: AD3L, STM2, PS2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRCA1 | 1 hits |
| 2 | CCNA2 | 1 hits |
| 3 | EGF | 1 hits |
| 4 | IGF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7553629 | The increase in BRCA1 expression upon stimulation with estrogen was not coordinated with the early induction of the estrogen-dependent pS2 gene but closely paralleled the delayed increase in the S-phase dependent marker cyclin A. |
| 2 | 9010238 | Four lines of evidence lead us to conclude that E2 induces BRCA1 primarily through an increase in DNA synthesis: (1) The kinetics and magnitude of induction are different from the directly E2 inducible gene, pS2; (2) Induction of BRCA1, but not pS2, is blocked by cycloheximide indicating that de novo protein synthesis is required; (3) Other hormonal and growth factor treatments that induce DNA synthesis have a similar effect, including IGF-1, EGF and DNA synthetic flares induced by tamoxifen and retinoic acid; (4) BRCA1 genomic fragments near the 5' end of the gene containing putative estrogen response elements fail to respond to E2 when transfected into breast cancer cell lines. |