Gene Information
Gene symbol: TOP2A
Gene name: topoisomerase (DNA) II alpha 170kDa
HGNC ID: 11989
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRCA1 | 1 hits |
| 2 | ERBB2 | 1 hits |
| 3 | GPR148 | 1 hits |
| 4 | HSD17B1 | 1 hits |
| 5 | HSD17BP1 | 1 hits |
| 6 | KRT122P | 1 hits |
| 7 | RARA | 1 hits |
| 8 | THRA | 1 hits |
| 9 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8244380 | Likelihood ratios of at least 1000:1 support the 10-locus framework order: cen-D17S250-ERBB2-(THRA1, TOP2A)-D17S855-PPY-D17S190-MTBT1-GP3A++ +-BTR-D17S588-tel. |
| 2 | 8460635 | Our localization of RARA, TOP2, EDH17B1 and 2, and possibly WNT3, between THRA1 and D17S181, two markers known to flank BRCA1, suggests that any of these is a potential candidate for the BRCA1 locus. |
| 3 | 9781655 | To determine whether there are any molecular markers that might help explain this paradox between pathologically aggressive neoplasms in patients with HBC and the lack of extreme clinically aggressive disease, we studied several molecular parameters in a group of 34 breast cancer patients with mutations in either the BRCA1 or BRCA2 tumor suppressor genes and compared them with a group of 20 breast cancer patients with non-HBC. |
| 4 | 9781655 | In general, patients with HBC had tumors that were of higher nuclear grade, contained a higher population of proliferating cells, showed increased expression of DNA topoisomerase II-alpha (topo II-alpha), lacked hormone receptors, and were more likely to show immunopositivity for the p53 tumor suppressor gene. |