Gene Pair Information
Gene Pair: BRCA1P1, BRCA1
Related Sentences
| # | PMID | Sentence |
| 1 | 9215675 | Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. |
| 2 | 9215675 | We have identified a new gene, NBR2, which is partially related to the NBR1 gene (formerly known as 1A1-3B and mapping directly adjacent to the pseudo-BRCA1 gene) and which lies head to head with the BRCA1 gene. |
| 3 | 9215675 | The physical distance between the transcription start sites of the NBR2 and BRCA1 genes is 218 bp, suggesting that regulation of the expression of both genes may be co-ordinated through a bi-directional promoter. |
| 4 | 9215675 | The NBR2 gene contains five exons spanning a genomic region of approximately 30 kb between the BRCA1 and pseudo-BRCA1 genes. |
| 5 | 33476590 | Patients carrying mutations in breast cancer susceptibility genes like BRCA1 and BRCA2 (BRCA1/2) account for 5-10% of all breast cancer patients. |
| 6 | 33476590 | Four novel variants (BRCA2 L1390W, BRCA2 Glu432fs, BRCA1 P706L, and BRCA1 Cys882fs) were identified. |
| 7 | 33476590 | BRCA2 Glu432fs decreased the expression of BRCA2 protein, enhanced cell migration and invasion ability, and prevented the protein from interacting with RAD51, resulting in a defect in the homologous recombination pathway. |
| 8 | 33775137 | High-risk women can be identified by a mutation detection in predisposing gene like BRCA1 or BRCA2. |