Gene Pair Information
Gene Pair: BRPF1, BRD4
Related Sentences
| # | PMID | Sentence |
| 1 | 34813314 | Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer. |
| 2 | 34813314 | Targeting poly(ADP-ribose) polymerase1/2 (PARP1/2) is a promising strategy for the treatment of pancreatic cancer with breast cancer susceptibility gene (BRCA) mutation. |
| 3 | 34813314 | Inducing the deficiency of homologous recombination (HR) repair is an effective way to broaden the indication of PARP1/2 inhibitor for more patients with pancreatic cancer. |
| 4 | 34813314 | Bromodomain-containing protein 4 (BRD4) repression has been reported to elevate HR deficiency. |
| 5 | 34813314 | Therefore, we designed, synthetized, and optimized a dual PARP/BRD4 inhibitor <b>III</b>-<b>16</b>, with a completely new structure and high selectivity against PARP1/2 and BRD4. |
| 6 | 34813314 | The advantages of <b>III</b>-<b>16</b> over Olaparib suggest that dual PARP/BRD4 inhibitors are novel and promising agents for the treatment of advanced pancreatic cancer. |