Gene Pair Information
Gene Pair: PTEN, TP53
Related Sentences
| # | PMID | Sentence |
| 1 | 11004669 | Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer. |
| 2 | 11004669 | Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer a lifetime risk of malignancy. |
| 3 | 11004669 | We studied a series of 120 sporadic breast carcinomas using microsatellite markers to identify LOH of BRCA1, BRCA2, p53 and PTEN. |
| 4 | 11004669 | LOH of the 4 loci did not occur independently; there were highly significant associations between LOH of BRCA1 and both BRCA2 (p < 0.001) and p53 (p < 0.001). |
| 5 | 34933735 | Also, MLH3 is a DNA mismatch repair gene and mutation in this gene is harmful in different cancers. |
| 6 | 34933735 | We identified 26 variants in breast cancer patients, 22 inherited variants were found in MLH3, CHECK2, BRCA1, BRCA2, BLM, TP53, MSH6, NBN and PTEN genes and 4 somatic variants were found in PALB2, RAD50 and RBM10 genes. |
| 7 | 35180531 | Comparison of mutational profiles between triple-negative and hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancers in T2N0-1M0 stage: Implications of TP53 and PIK3CA mutations in Korean early-stage breast cancers. |
| 8 | 35180531 | Therefore, we compared the mutation profiles of early TNBC with those of hormone receptor-positive (HR+) and/or human epidermal growth factor receptor 2-negative (HER2-) breast cancer using a customized next-generation sequencing capture panel. |
| 9 | 35180531 | Significant mutations were found in TP53, PIK3CA, AR, BRCA1, PTEN, BRCA2, BRIP2, KIT, MET, AKT1, ALK, BARD1, BRAF, CD274, ERBB2, FGFR1, IDH2, NOTCH1, RET, and STK11 (in descending order of occurrence). |
| 10 | 35180531 | TP53 mutations were identified in the TNBC group more frequently than in the HR+/HER2- group (P = 0.003). |
| 11 | 35180531 | The presence of TP53 mutations was associated with a higher tumor grade (P = 0.008), p53 positivity (P < 0.0001), and a higher Ki-67 index (P = 0.004). |
| 12 | 35180531 | PIK3CA was the most frequently mutated gene in HR+/HER2- breast cancer (8/22, 36.4%), but not in TNBC (1/12, 8.3%). |
| 13 | 35180531 | The TP53 mutation is associated with higher tumor grade and Ki-67 expression in both groups, and with larger tumor size in TNBC, but not in HR+/HER2- breast cancer. |
| 14 | 17292821 | BRCA1 and BRCA2 mutations confer very high risks of breast and ovarian cancer. p53 and PTEN mutations lead to very high breast cancer risks associated with rare cancer syndromes. |
| 15 | 17292821 | Mutations in CHEK2, ATM, NBS1, RAD50, BRIP1, and PALB2 are associated with doubling of breast cancer risks. |
| 16 | 17292821 | In addition, biallelic mutations in BRCA2, BRIP1, and PALB2 cause Fanconi anemia. |