Ignet

Gene Pair Information

Gene Pair: FLT1, VEGFA

Related Sentences

#	PMID	Sentence
1	9621286	The ability of VEGF to be chemotactic for monocytes and to increase the activity of collagenase and plasminogen activator may have implications for renal development and renal disease.
2	9621286	In humans, the cellular actions of VEGF depend on binding to two specific receptors: Flt-1 and KDR.
3	9621286	The aims of this study were: (1) to localize VEGF receptor proteins in human renal ontogenesis; (2) to quantify VEGF binding in human fetal and adult kidney; and (3) to dissect the binding into its two known components: the KDR and Flt-1 receptors.
4	9621286	The latter aim was achieved by competitive binding of VEGF and placenta growth factor-2, which only binds to Flt-1.
5	9621286	By double-label immunohistochemistry, VEGF receptor proteins were localized solely to endothelial cells of preglomerular vessels, glomeruli, and postglomerular vessels.
6	9621286	In developing glomeruli, VEGF receptor protein appeared as soon as endothelial cells were positive for von Willebrand factor.
7	9621286	Placenta growth factor-2 displaced VEGF binding in all renal structures by approximately 60%.
8	9621286	VEGF receptor proteins thus were found only in renal endothelial cells.
9	9621286	A coexpression of both VEGF binding sites could be shown, with Flt-1 demonstrating the most abundant VEGF receptor binding sites in the kidney.
10	10864579	Vascular endothelial growth factor (VEGF), a potent mitogen, is expressed in podocytes in the glomerulus, and VEGF receptors (flt-1, KDR, and neuropilin-1) are present on endothelial cells and other cell types.
11	10864579	In contrast, mesangial flt-1 and KDR receptor staining were both clearly seen in biopsy samples from proliferative renal diseases.
12	10864579	In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation.
13	10864579	In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease.