Ignet

Gene Pair Information

Gene Pair: BARD1, BRCA2

Related Sentences

#	PMID	Sentence
1	9798686	Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein.
2	9798686	During S phase of the cell cycle, BRCA1 polypeptides are found in discrete nuclear bodies ('BRCA1 nuclear dots') together with HsRad51, a human homolog of the E. coli recA protein, and BARD1, a protein that interacts with BRCA1 to form a stable heterodimer.
3	9798686	BARD1 is structurally similar to BRCA1 in that both molecules harbor an amino-terminal RING domain and two carboxy-terminal BRCT domains.
4	9798686	However, the remaining sequences of BARD1 display a markedly lower degree of phylogenetic conservation, comparable to those reported for BRCA1 and BRCA2.
5	9798686	Moreover, murine Bard1 retains the ability to associate in vivo with BRCA1, and its expression pattern in adult mice mirrors that of Brca1, with elevated levels of RNA transcripts found in the testes and spleen.
6	9798686	These data suggest that BRCA1 and BARD1 have co-evolved to participate in a common pathway of tumor suppression.
7	9894790	A role for BRCA1 and BRCA2 in the control of genome integrity easily fits a tumor suppressor model.
8	9894790	The studies summarized here suggest that BRCA1, BRCA2, RAD51. and BARD1 function as a biochemical complex.
9	9894790	Experimental data suggest that BRCA1 and BRCA2 function as regulators of transcription.
10	9894790	Are the DNA repair and transcriptional regulatory functions of BRCA1 and BRCA2 related?
11	9894790	BRCA1 and BRCA2 may maintain the integrity of the genome by regulating expression of genes directly involved in this process.
12	9894790	If BRCA1 and BRCA2 are ubiquitously expressed, why do mutations in BRCA1 and BRCA2 lead specifically to tumors primarily of the breast and ovary, as well as a limited number of other tissues to a lesser degree?
13	9894790	Nothing to date has been revealed that would explain how alteration of the transcriptional regulatory function and or the DNA repair function ascribed to BRCA1 and BRCA2 would result in tumor specificity as both of these functions are essential to a broad spectrum of tissues.
14	9894790	It is possible that BRCAI and BRCA2 may regulate genes expressed only in the breast and ovary.
15	9894790	Similarly, there may be unidentified BRCA1 and BRCA2 co-factors that are active only in the breast and ovary and, therefore, are critical to tumorigenesis.
16	10195418	The function of BRCA1 has been examined in gene knockout mice in which the nullizygous mice die early in utero, but this lethality can be partially rescued by a nullizygous p53 mutation.
17	10195418	Wild-type BRCA1 protein binds to a number of cellular proteins, including DNA repair protein Rad51, tumor suppressor p53, RNA polymerase II holoenzyme, RNA helicase A, CtBP-interacting protein, c-myc, BRCA1-associated RING domain protein (BARD1), BRCA2 protein, etc.