Gene Pair Information
Gene Pair: BARD1, PCNA
Related Sentences
| # | PMID | Sentence |
| 1 | 9267023 | BARD1 and Rad51, two proteins associated with the BRCA1 dots, behaved similarly. |
| 2 | 9267023 | The S phase BRCA1 phosphorylation response to DNA damage occurred in cells lacking, respectively, two DNA damage-sensing protein kinases, DNA-PK and Atm, implying that neither plays a prime role in this process. |
| 3 | 9267023 | Finally, after BRCA1 dot dispersal, BRCA1, BARD1, and Rad51 accumulated, focally, on PCNA+ replication structures, implying an interaction of BRCA1/BARD1/Rad51 containing complexes with damaged, replicating DNA. |
| 4 | 9645467 | In Saccharomyces cerevisiae PRR is controlled by the RAD61RAD18 pathway which involves POL30 gene encoding proliferating cell nuclear antigen (PCNA), and in human cells PCNA is known to be closely associated with the newly replicated chromatin where PRR probably takes place. |
| 5 | 9645467 | In UV-irradiated human cells distinct PCNA foci may be detected in some cells which accumulate phosphorylated breast cancer susceptibility protein BRCA1 and another protein BARD1. |
| 6 | 9645467 | In this study we found that the known inhibitor of protein kinases staurosporine supresses PRR in NER-deficient cells which is consistent with the view that BRCA1 and PCNA are required for PRR. |
| 7 | 9645467 | Since RAD18 protein is not essential for normal DNA replication and directly controls PRR in yeast, we analysed whether this protein as well as its human homologs (HR18A and HR18B) have common domains with BRCA1 and BARD1. |
| 8 | 9645467 | It is found that HR18A has a subregion of homology to BARD1 and HR18A-to BRCA1. |
| 9 | 9645467 | Taken together the results indicate that BRCA1 and BARD1 may be involved in PRR in human cells. |