Gene Pair Information
Gene Pair: BRCA1, NR1I2
Related Sentences
| # | PMID | Sentence |
| 1 | 9645467 | In Saccharomyces cerevisiae PRR is controlled by the RAD61RAD18 pathway which involves POL30 gene encoding proliferating cell nuclear antigen (PCNA), and in human cells PCNA is known to be closely associated with the newly replicated chromatin where PRR probably takes place. |
| 2 | 9645467 | In UV-irradiated human cells distinct PCNA foci may be detected in some cells which accumulate phosphorylated breast cancer susceptibility protein BRCA1 and another protein BARD1. |
| 3 | 9645467 | In this study we found that the known inhibitor of protein kinases staurosporine supresses PRR in NER-deficient cells which is consistent with the view that BRCA1 and PCNA are required for PRR. |
| 4 | 9645467 | Since RAD18 protein is not essential for normal DNA replication and directly controls PRR in yeast, we analysed whether this protein as well as its human homologs (HR18A and HR18B) have common domains with BRCA1 and BARD1. |
| 5 | 9645467 | It is found that HR18A has a subregion of homology to BARD1 and HR18A-to BRCA1. |
| 6 | 9645467 | Taken together the results indicate that BRCA1 and BARD1 may be involved in PRR in human cells. |