Gene Pair Information
Gene Pair: BRCA1, PCNA
Related Sentences
| # | PMID | Sentence |
| 1 | 9121124 | To determine the relationship between Brca1 expression and cell cycle, serial and adjacent sections of ovary were evaluated for proliferating cell nuclear antigen by immunohistochemistry. |
| 2 | 9121124 | In all cases, Brca1 expression correlated to S-phase proliferating cell nuclear antigen nuclear staining. |
| 3 | 9267023 | BARD1 and Rad51, two proteins associated with the BRCA1 dots, behaved similarly. |
| 4 | 9267023 | The S phase BRCA1 phosphorylation response to DNA damage occurred in cells lacking, respectively, two DNA damage-sensing protein kinases, DNA-PK and Atm, implying that neither plays a prime role in this process. |
| 5 | 9267023 | Finally, after BRCA1 dot dispersal, BRCA1, BARD1, and Rad51 accumulated, focally, on PCNA+ replication structures, implying an interaction of BRCA1/BARD1/Rad51 containing complexes with damaged, replicating DNA. |
| 6 | 9467943 | Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. |
| 7 | 9467943 | The mouse homologues of the breast cancer susceptibility genes, Brca1 and Brca2, are expressed in a cell cycle-dependent fashion in vitro and appear to be regulated by similar or overlapping pathways. |
| 8 | 9467943 | Therefore, we compared the non isotopic in situ hybridization expression patterns of Brca1 and Brca2 mRNA in vivo in mitotic and meiotic cells during mouse embryogenesis, mammary gland development, and in adult tissues including testes, ovaries, and hormonally altered ovaries. |
| 9 | 9467943 | Brca1 and Brca2 are expressed concordantly in proliferating cells of embryos, and the mammary gland undergoing morphogenesis and in most adult tissues. |
| 10 | 9467943 | The expression pattern of Brca1 and Brca2 correlates with the localization of proliferating cell nuclear antigen, an indicator of proliferative activity. |
| 11 | 9467943 | In the ovary, Brca1 and Brca2 exhibited a comparable hormone-independent pattern of expression in oocytes, granulosa cells and thecal cells of developing follicles. |
| 12 | 9467943 | In the testes, Brca1 and Brca2 were expressed in mitotic spermatogonia and early meiotic prophase spermatocytes. |
| 13 | 9467943 | Northern analyses of prepubertal mouse testes revealed that the time course of Brca2 expression was delayed in spermatogonia relative to Brca1. |
| 14 | 9467943 | Thus, while Brca1 and Brca2 share concordant cell-specific patterns of expression in most proliferating tissues, these observations suggest that they may have distinct roles during meiosis. |
| 15 | 9645467 | In Saccharomyces cerevisiae PRR is controlled by the RAD61RAD18 pathway which involves POL30 gene encoding proliferating cell nuclear antigen (PCNA), and in human cells PCNA is known to be closely associated with the newly replicated chromatin where PRR probably takes place. |
| 16 | 9645467 | In UV-irradiated human cells distinct PCNA foci may be detected in some cells which accumulate phosphorylated breast cancer susceptibility protein BRCA1 and another protein BARD1. |
| 17 | 9645467 | In this study we found that the known inhibitor of protein kinases staurosporine supresses PRR in NER-deficient cells which is consistent with the view that BRCA1 and PCNA are required for PRR. |
| 18 | 9645467 | Since RAD18 protein is not essential for normal DNA replication and directly controls PRR in yeast, we analysed whether this protein as well as its human homologs (HR18A and HR18B) have common domains with BRCA1 and BARD1. |
| 19 | 9645467 | It is found that HR18A has a subregion of homology to BARD1 and HR18A-to BRCA1. |
| 20 | 9645467 | Taken together the results indicate that BRCA1 and BARD1 may be involved in PRR in human cells. |