Gene Pair Information
Gene Pair: CCND1, PGR
Related Sentences
| # | PMID | Sentence |
| 1 | 9893652 | There is controversy concerning the prognosis of breast cancers arising in women carrying loss of function mutations in the breast cancer susceptibility genes BRCA1 and BRCA2. |
| 2 | 9893652 | We used quantitative immunohistochemical analysis for the oestrogen receptor (ER), progesterone receptor (PgR), cyclin D1 and pS2 on sections of primary tumours and ductal carcinoma in situ (DCIS). |
| 3 | 9893652 | Expression of PgR (P < 0.05) and cyclin D1 (P < 0.01) was low in the BRCA1- and BRCA2-associated cancers compared with sporadic cases. |
| 4 | 9893652 | The low frequency of expression of ER (9/40), PgR (2/40) cyclin D1 (5/36) and pS2 (5/36) in the familial tumours indicates that the majority of such tumours will be oestrogen insensitive and unlikely to respond to hormonal manipulation even at the in situ stage in their evolution. |
| 5 | 9893652 | The low level of PgR (2/40 cases) suggests that there may be some abnormality of transactivating function of the ER in these tumours. |