Gene Pair Information
Gene Pair: ERBB2, SH3PXD2A
Related Sentences
| # | PMID | Sentence |
| 1 | 8872329 | FISH detection of HER-2/neu oncogene amplification in early onset breast cancer. |
| 2 | 8872329 | HER-2/neu (c-erbB-2) gene amplification based on Southern blotting or immunohistochemistry has been shown to be predictive of poor outcome in breast cancer occurring in women over 40, but there is little data on the role of HER-2/neu in young women with breast cancer, many of whom may have inherited BRCA1 or other predisposing genes. |
| 3 | 8872329 | The present study used fluorescent in situ hybridization (FISH) on archival specimens of breast cancer from 37 women under the age of 40 to evaluate the role of HER-2/neu amplification in this cohort, and to also evaluate the efficacy of FISH for quantifying amplification. |
| 4 | 8872329 | Thus, this study demonstrates that FISH is a reproducible and sensitive technique for detecting HER-2/neu amplification, and that amplification of the oncogene is the strongest independent indicator of recurrence of breast cancer in young women. |