Gene Pair Information
Gene Pair: INS, IGFBP4
Related Sentences
| # | PMID | Sentence |
| 1 | 7507078 | The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer. |
| 2 | 7507078 | The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. |
| 3 | 7507078 | Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. |
| 4 | 7507078 | IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. |
| 5 | 7507078 | IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1. |