Ignet

Gene Pair Information

Gene Pair: RAD51, BRCA2

Related Sentences

#	PMID	Sentence
1	9192668	RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
2	9192668	RAD51 interacts with proteins involved in recombination and also with tumor suppressor proteins p53 and breast cancer susceptibility gene 1 (BRCA1).
3	9192668	RAB163 encodes the C-terminal portion of mouse BRCA2, the homologue of the second breast cancer susceptibility gene protein in humans, demonstrating an in vitro association between RAD51 and BRCA2.
4	9774970	Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
5	9774970	BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51.
6	9774970	Results presented here show that BRCA1 and BRCA2 coexist in a biochemical complex and colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes.
7	9774970	Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation.
8	9774970	Thus, BRCA1 and BRCA2 participate, together, in a pathway(s) associated with the activation of double-strand break repair and/or homologous recombination.
9	9894790	A role for BRCA1 and BRCA2 in the control of genome integrity easily fits a tumor suppressor model.
10	9894790	The studies summarized here suggest that BRCA1, BRCA2, RAD51. and BARD1 function as a biochemical complex.
11	9894790	Experimental data suggest that BRCA1 and BRCA2 function as regulators of transcription.
12	9894790	Are the DNA repair and transcriptional regulatory functions of BRCA1 and BRCA2 related?
13	9894790	BRCA1 and BRCA2 may maintain the integrity of the genome by regulating expression of genes directly involved in this process.
14	9894790	If BRCA1 and BRCA2 are ubiquitously expressed, why do mutations in BRCA1 and BRCA2 lead specifically to tumors primarily of the breast and ovary, as well as a limited number of other tissues to a lesser degree?
15	9894790	Nothing to date has been revealed that would explain how alteration of the transcriptional regulatory function and or the DNA repair function ascribed to BRCA1 and BRCA2 would result in tumor specificity as both of these functions are essential to a broad spectrum of tissues.
16	9894790	It is possible that BRCAI and BRCA2 may regulate genes expressed only in the breast and ovary.
17	9894790	Similarly, there may be unidentified BRCA1 and BRCA2 co-factors that are active only in the breast and ovary and, therefore, are critical to tumorigenesis.
18	10195418	The function of BRCA1 has been examined in gene knockout mice in which the nullizygous mice die early in utero, but this lethality can be partially rescued by a nullizygous p53 mutation.
19	10195418	Wild-type BRCA1 protein binds to a number of cellular proteins, including DNA repair protein Rad51, tumor suppressor p53, RNA polymerase II holoenzyme, RNA helicase A, CtBP-interacting protein, c-myc, BRCA1-associated RING domain protein (BARD1), BRCA2 protein, etc.
20	10197592	BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway.
21	10197592	The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode products that each interact with the product of the eukaryotic RecA homologue, hRad51.
22	10197592	We have recently found that BRCA1 and BRCA2 coexist in a common biochemical complex.
23	10197592	Thus, BRCA1 and BRCA2 participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair.
24	10197592	The BRCA1/BRCA2 complex may function in postreplicational repair processes activated during the DNA synthesis stage of the cell cycle.
25	10362364	Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
26	10362364	Association of breast tumor susceptibility gene products BRCA1 and BRCA2 with the RAD51 recombination protein suggested that cancer could arise through defects in recombination.
27	10362364	The identification of NBS1, responsible for Nijmegen breakage syndrome, from the MRE11/RAD50 recombination protein complex also supports this hypothesis.
28	10362364	These findings suggest that RAD54B may play an active role in recombination processes in concert with other members of the RAD52 epistasis group.
29	10362365	Association of a recombinational repair protein RAD51 with tumor suppressors BRCA1 and BRCA2 suggests that defects in homologous recombination are responsible for tumor formation.
30	10362365	Also recent findings that a protein associated with the MRE11/RAD50 repair complex is mutated in Nijmegen breakage syndrome characterized by increased cancer incidence and ionizing radiation sensitivity strongly support this idea.
31	10362365	Since RAD51 forms a complex with other members of the RAD52 epistasis group and with BRCA proteins, it is reasonable to ask if alterations of members of the RAD52 epistasis group lead to tumor development.